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Mice lacking the TIMP4 gene showed increased inflammation, indicating its anti-inflammatory role in diseases.

Tissue inhibitor of metalloproteinases 4 (TIMP4) belongs to a crucial family of proteins designed to keep the body’s extracellular matrix (ECM) in balance. It acts as an inhibitor of matrix metalloproteinases (MMPs), which are enzymes that break down connective tissue. Titlimp4

Specific genetic variations (C>T polymorphism) in the TIMP4 gene have been associated with a protective effect against preeclampsia in pregnant women. TIMP4 vs. Other TIMPs Mice lacking the TIMP4 gene showed increased inflammation,

The decrease in TIMP4 serves as a strong indicator of a poor prognosis, positioning it as a novel potential biomarker for tracking tumor progression. 2. Cardiovascular and Inflammation Protection Titlimp4