: In England, Queen Elizabeth I (Rachel Skarsten) readies herself for war against Spain and the Catholic Church. Despite their rivalry, Elizabeth comes to realize that she and Mary are mirrored souls—two powerful women besieged by men who seek to control or destroy them.
: Catherine de' Medici (Megan Follows) sees her storyline conclude in a "completely Catherine" fashion, involving a dark deal with a witch and a bizarre ménage-à-trois to protect her power and her mentally fragile son, King Charles. The Execution and The Afterlife All It Cost Her - Reign Wiki [S4E16] All It Cost Her
: To secure her son's future and her own safety, Mary makes the fateful decision to have Lord Darnley killed, an act that ultimately provides her enemies with the leverage needed to turn Scotland against her. : In England, Queen Elizabeth I (Rachel Skarsten)