Go to Edit > Preferences > Audio . Select your audio interface's ASIO driver . Set the Sample Rate (typically 44.1 or 48 kHz) and Buffer Size (lower values like 256 reduce latency for recording).
When you first launch Reason 12.5.0, you must configure your hardware: Reason Studios Reason 12.5.0 [WiN]
In Preferences > Control Surfaces , use "Easy MIDI Inputs" to auto-detect your MIDI keyboard or controller. Go to Edit > Preferences > Audio