In the third episode of Made in Abyss , "Departure," Riko and Reg prepare to leave the orphanage, sharing emotional goodbyes, particularly with Nat, before beginning their descent. While the episode focuses on their emotional departure from the surface, it also highlights the quiet support of their mentor, Jiruo. You can watch a detailed review of Episode 3 that discusses the emotional character interactions and world-building as the journey truly begins: Made in Abyss - Episode 3 Review | Departure .