If the mouse stops working suddenly while playing, try these quick steps: I'm having trouble with san andreas and my mouse. : r/GTA

If you don't want to download third-party files, you can manually force the game to run on a single CPU core, which is often the cause of the glitch. Launch GTA San Andreas and out of the game.

Return to the game. You may need to repeat this every time you launch the game unless you create a custom batch file to automate it.

Open (Ctrl+Shift+Esc) and go to the Details tab. Right-click gta_sa.exe and select Set Affinity . Uncheck All Processors and select only CPU 0 .

If your mouse is stuck or clicking doesn't work in Grand Theft Auto: San Andreas on Windows 10, it is likely because the game was not designed for modern multi-core processors or newer DirectInput versions.

: Right-click the GTA SA shortcut on your desktop and select Open file location .

: Launch GTA SA, and your mouse should now function correctly every time you play. Alternative Method: Set CPU Affinity

: Drag and drop the downloaded dinput8.dll file into the main folder where gta_sa.exe is located.