Agammaglobulinemia is a rare genetic disorder where the immune system cannot produce enough (immunoglobulins) to fight off germs . People with this condition have very low levels of protective proteins, making them highly susceptible to severe and frequent infections. Core Characteristics
: The body fails to develop mature B lymphocytes, which are the white blood cells responsible for creating antibodies. agammaglobulinemia
: Also known as Bruton's agammaglobulinemia , this accounts for 85–90% of cases and primarily affects males because the gene is on the X chromosome. Agammaglobulinemia is a rare genetic disorder where the
: A rarer form that can affect both males and females, caused by mutations in other genes like IGHM or CD79A . Symptoms & Complications : Also known as Bruton's agammaglobulinemia , this
Symptoms usually appear between as maternal antibodies fade. X-Linked Agammaglobulinemia - StatPearls - NCBI Bookshelf