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💡 Proteoglycans are no longer seen as just "cellular glue." They are dynamic regulators of the tumor microenvironment that determine how fast a tumor grows and how it responds to treatment.

Proteoglycan 4 (PRG4) has shown potential in making current chemotherapy drugs (like sorafenib) more effective by interfering with cancer cell resistance. 27879.rar

Found to be upregulated in the HCC microenvironment, agrin promotes cancer cell proliferation and "stiffness" of the tumor tissue, which helps the cancer spread. 💡 Proteoglycans are no longer seen as just "cellular glue

Proteoglycans in Cancer: The Case of Hepatocellular Carcinoma (HCC) 27879.rar

Measuring levels of GPC3 or SDC1 in the blood allows for earlier detection of liver cancer compared to traditional methods.