-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling
The team used HEK293 cells and techniques like fluorescence recovery after photobleaching (FRAP) to measure how fast proteins move within the cell. Where to Find the Paper and Videos Full Text (HTML/PDF): Available at eLife Sciences.
-catenin into the nucleus in real-time. They found that while 16748mp4
You can download the supporting MP4 files directly from the eLife article page under the "Figures and data" section or via PubMed Central.
Published in (2016), this study uses live-cell imaging and mathematical modeling to understand how cells process signals from the Wnt pathway, which is critical for development and often deregulated in cancer. They found that while You can download the
The paper relies heavily on time-lapse movies to visualize these cellular dynamics. For example, Video 2 (referenced as part of eLife 16748) shows the accumulation and eventual egress of YFP- -catenin in cells treated with Wnt3a.
-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling" , which is identified by the digital object identifier (DOI) 10.7554/eLife.16748 . For example, Video 2 (referenced as part of
-catenin levels rise steadily after activation, the actual transcription of the target gene ( CCND1 ) occurs in "bursts" rather than a constant stream.